2-氨基-4-(4-甲氧基苯基)嘧啶合成路线 （共 4 条）
反应条件
1: 4-methoxy-benzoyl chloride; trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in acetonitrile T=20°C; Sonogashira coupling; 1 h; 2: 1-methylguanidine hydrochloride With sodium carbonate in methanol; acetonitrile 14 h; Heating;
参考文献
Karpov, Alexei S.; Mueller, Thomas J. J.
Organic Letters, 2003 , vol. 5, # 19 p. 3451 - 3454
反应条件
1: NEt3; CuI / Pd(PPh3)2Cl2 / acetonitrile; methanol / 1 h / 20 °C 2: 99 mg / Na2CO3*10H2O / acetonitrile; methanol / 14 h / Heating View Scheme
参考文献
Synthesis, , # 18 p. 2815 - 2826
反应条件
sodium carbonate in methanol; acetonitrile 14 h; Heating;
参考文献
Karpov, Alexei S.; Mueller, Thomas J. J.
Synthesis, 2003 , # 18 p. 2815 - 2826
参考文献
Chemische Berichte, , vol. 63, p. 2601,2607
