6-(氯甲基)-n-(4-甲基苯基)-1,3,5-三嗪-2,4-二胺合成路线 （共 2 条）
反应条件
1: p-Tolylbiguanide hydrochloride With sodium methylate in methanol
T=20°C; 3 h;
2: chloroacetic acid ethyl ester in methanol
T=20°C; 48 h;
参考文献
Maarouf, Azza R.; Farahat, Abdelbasset A.; Selim, Khalid B.; Eisa, Hassan M.
Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 703 - 710
反应条件
1.1: hydrogenchloride / water / Reflux
2.1: sodium methylate / methanol / 3 h / 20 °C
2.2: 48 h / 20 °C
View Scheme
参考文献
Maarouf, Azza R.; Farahat, Abdelbasset A.; Selim, Khalid B.; Eisa, Hassan M.
Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 703 - 710
