1: With 4-methyl-morpholine in N,N-dimethyl-formamide T=20°C; Addition; 24 h; 2: With trifluoroacetic acid in chloroform Hydrolysis; deprotection;

in hydrogen fluoride

1.1: 4-toluenesulfonic acid; H2 / Pd/C / dimethylformamide / 48 h 2.1: N-methylmorpholine / dimethylformamide / 24 h / 20 °C 2.2: 54 percent / TFA, 50 percent / CHCl3 View Scheme

Multistep reaction;