5-溴-2-(哌嗪-1-基)嘧啶合成路线 （共 4 条）
反应条件
bromine; calcium carbonate in water T=50 - 55°C; 2 h;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
hydrogenchloride; water Heating / reflux;
参考文献
US2005/234046 A1, ;
Page/Page column 62 ;
US 20050234046 A1
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in toluene T=110°C; 24 h; Inert atmosphere;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BROCKSCHNIEDER, Damian
Patent: WO2011/110488 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
potassium carbonate in acetone 3 h; Heating / reflux;
参考文献
PROLYSIS LTD
Patent: WO2009/74812 A1, 2009 ;
Location in patent: Page/Page column 52 ;
WO 2009/074812 A1
