2-氯-1-(8-羟基喹啉-5-基)乙酮合成路线 （共 4 条）
反应条件
1: With AlCl3, aluminium chloride in nitrobenzene
T=0 - 100°C; 35 h; Inert atmosphere;
2: With hydrogenchloride; water
T=20°C; 72 h;
3: With sodium acetate
pH=6;
参考文献
VARINEL, INC.; ZURAWSKI, Vincent, R.; NITZ, Theodore, J.
Patent: WO2013/115793 A1, 2013 ;
Location in patent: Page/Page column 16-17 ;
反应条件
nitrobenzene
T=100°C;
参考文献
Burger et al.
Journal of Organic Chemistry, 1944 , vol. 9, p. 373,377
反应条件
potassium hydroxide; aluminium trichloride
Yield given;
参考文献
Mohrle; Schaltenbrand
Pharmazie, 1985 , vol. 40, # 5 p. 307 - 311
反应条件
in ethanol
5 h; Heating;
参考文献
Abdel-Mohsen, Shawkat A.
Journal of the Chinese Chemical Society, 2003 , vol. 50, # 5 p. 1085 - 1092
