3-羟基-1,1-环丁烷二羧酸-1,1-二乙酯合成路线 （共 6 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate T=20°C; P=760.051 Torr; 12 h;
参考文献
Satoh, Tsuyoshi; Kimura, Tsutomu; Sasaki, Yuki; Nagamoto, Shinobu
Synthesis (Germany), 2012 , vol. 44, # 13 art. no. SS-2012-F0243-OP, p. 2091 - 2101
反应条件
1: sodium ethylate; benzene / 170 °C 2: palladium; ethanol / Hydrogenation View Scheme
参考文献
Chemische Berichte, , vol. 90, p. 1424,1427
反应条件
1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C 2: diethylamino-sulfur trifluoride / dichloromethane / 20 °C 3: potassium hydroxide / water; ethanol / 20 °C / |Cooling with ice 4: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / |Reflux 5: lithium hydroxide hydrate / water; tetrahydrofuran; methanol / 20 °C View Scheme
参考文献
IRM LLC; YEH, Vince; LI, Xiaolin; LIU, Xiaodong; LOREN, Jon; MOLTENI, Valentina; NABAKKA, Juliet; NGUYEN, Bao; PETRASSI, Hank Michael James
Patent: US2013/59846 A1, 2013 ;
反应条件
1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C 2: diethylamino-sulfur trifluoride / dichloromethane / 20 °C 3: potassium hydroxide; water / ethanol / 20 °C / Cooling with ice 4: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 5 h / Reflux 5: lithium borohydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
参考文献
MEDIVIR UK LIMITED; AYESA, Susana; GRABOWSKA, Urszula; HEWITT, Ellen; JOeNSSON, Daniel; KLASSON, Bjoern; KAHNBERG, Pia; LUNDGREN, Stina; TEJBRANT, Jan; WIKTELIUS, Daniel
Patent: WO2011/158197 A1, 2011 ;
WO 2011/158197 A1
反应条件
1: With potassium hydroxide in ethanol
4 h; Heating / reflux;
2: With hydrogenchloride in ethanol; water
T=0°C; pH=1;
参考文献
Zhao, Jian; Gou, Shaohua; Sun, Yanyan; Yin, Runting; Wang, Zhimei
Chemistry - A European Journal, 2012 , vol. 18, # 45 p. 14276 - 14281
反应条件
1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 20 °C
View Scheme
参考文献
IRM LLC; YEH, Vince; LI, Xiaolin; LIU, Xiaodong; LOREN, Jon; MOLTENI, Valentina; NABAKKA, Juliet; NGUYEN, Bao; PETRASSI, Hank Michael James
Patent: US2013/59846 A1, 2013 ;
