1,2,3,4-四氢-6,7-二甲氧基喹啉合成路线 （共 12 条）
反应条件
borane-THF in tetrahydrofuran
T=0 - 20°C;
参考文献
Fan, Kuo-Hsien; Lever, John R.; Lever, Susan Z.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 1852 - 1859
参考文献
Taylor
Journal of the Chemical Society, 1951 , p. 1150,1155
Full Text Show Details
Pratesi; Castorina
Farmaco, Edizione Scientifica, 1954 , vol. 9, p. 205,209
反应条件
sodium hydroxide in ethanol
Hydrolysis; 6 h; Heating;
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: iron; acetic acid / 0.5 h / 80 °C
2: borane-THF / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Fan, Kuo-Hsien; Lever, John R.; Lever, Susan Z.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 1852 - 1859
反应条件
1: 96 percent / NaIO4 / methanol / 6 h / 20 °C
2: 84 percent / TFAA; BF3*Et2O / benzene / 1 h / 20 °C
3: 91 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C
4: 87 percent / 10 percent NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: Ac2O / 1 h / 60 °C
2: 96 percent / NaIO4 / methanol / 6 h / 20 °C
3: 84 percent / TFAA; BF3*Et2O / benzene / 1 h / 20 °C
4: 91 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C
5: 87 percent / 10 percent NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: 91 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C
2: 87 percent / 10 percent NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: 84 percent / TFAA; BF3*Et2O / benzene / 1 h / 20 °C
2: 91 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C
3: 87 percent / 10 percent NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: ethanol; Raney nickel / Hydrogenation
2: dioxane; lithium alanate
View Scheme
参考文献
Iwao; Tomino
Yakugaku Zasshi, 1956 , vol. 76, p. 814,816
Chem.Abstr., 1957 , p. 1178
反应条件
sulfuric acid
bei der elektrolytischen Reduktion an einer Blei-Kathode;
参考文献
Sugasawa et al.
Yakugaku Zasshi, 1938 , vol. 58, p. 402;engl.Ref.S.80
Chem.Abstr., 1938 , p. 6650
