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| CAS号 : | 58-15-1 |
精确质量 : | 231.13700 |
| 分子式 : | C13H17N3O |
logP : | 1.55040 |
| 分子量 : | 231.29400 |
PSA : | 30.17000 |
氨基比林 | |
aminophenazone | |
58-15-1 | |
C13H17N3O | |
231.29400 | |
30.17000 | |
1.55040 | |
231.13700 |
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1.614
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白色结晶粉末
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125.9ºC
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319.7ºC at 760mmHg
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107-109 °C(lit.)
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5.55 g/100 mL
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1.17g/cm3
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Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
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Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
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CD2625000
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6.1
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3
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S26-S36-S36/37/39
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III
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UN 2811 6.1/PG 3
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2933110000
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Xn
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R21/22; R36/37/38
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品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
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2933110000 二甲基苯基吡唑酮及其衍生物〔二甲基苯基吡唑酮即安替比林〕。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0% |
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2933110000 1,5-dimethyl-2-phenyl-1h-pyrazol-3(2h)-one。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0% General tariff:20.0% |
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HTS:2933110000.Phenazone (Antipyrine) and its derivatives.Rate general: 6.5%.Rate special: Free (A,AU,BH,CA,CL,CO,E,IL,J,JO,K,KR,MA,MX,OM,P,PA,PE,SG) |
1.由氨基安替比林经催化氢化(烃化)而得。溶解罐中先加水,加热至50-60℃,搅拌下投入氨基安替比林,全溶后倒入氢化罐中。用水洗涤溶解罐,与镍催化剂搅匀再加至氢化罐。将氢化罐抽真空,然后关闭真空阀,通入氢气,开动搅拌,待压力升至0.245MPa时,停止通氢。加入甲醛,继续通入氢气。加甲醛的速度以每加5L甲醛吸氢1.8-2立方米为标准,反应温度控制在60-85℃,甲醛加完后继续反应10min,测试终点。合格后压滤,滤液冷至25℃以下,析出结晶,甩滤得氨基比林粗品。将氨基比林粗品、乙醇、活性炭升温至75-80℃,搅拌脱色1h,压滤。滤液冷至10℃,析出结晶,甩滤,用乙醇洗涤,经气流干燥,得氨基比林。 | |
解热镇痛作用较强，缓慢而持久，消炎抗风湿作用与阿司匹林相似。 |
