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| CAS号 : | 630-93-3 |
精确质量 : | 274.07200 |
| 分子式 : | C15H11N2NaO2 |
logP : | 2.21300 |
| 分子量 : | 274.25000 |
PSA : | 49.41000 |
苯妥英钠 | |
Phenytoin sodium | |
630-93-3 | |
C15H11N2NaO2 | |
274.25000 | |
49.41000 | |
2.21300 | |
274.07200 |
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白色粉末
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Sensitive to light phenytoin a slight yellowing of the solution will not affect its potency. After being refrigerated, solution may form a precipitate which usually dissolves after being warmed to room temperature; however, do not use if the solution is no
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212.8ºC
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Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should b
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290-299ºC
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428.2ºC at 760 mmHg
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GHS07, GHS08 | |
警告 | |
H302; H317; H361 | |
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III
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6.1(b)
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2933990090
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UN 2811 6.1/PG 3
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3
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R22; R43; R62; R63
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S22-S36/37/39-S45
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MU1400000
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Xn
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2933990090. Heterocyclic compounds with nitrogen hetero-atom(s) only |
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品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
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2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
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2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
苯甲醛经缩合、氧化得到联苯甲酰，然后与尿素重排、环合得到苯妥英钠。将水、尿素及联苯甲酰依次加入反应锅，搅拌加热至98℃，加入30%氢氧化钠，回流1.5h。加水及适量少性炭脱色，冷至26-28℃，过滤，滤液用5%左右盐酸酸化至pH=5-6，温度45-55℃，过滤，用水洗涤，得苯妥英。将苯妥英投入碱液中加热溶解，用氢氧化钠溶液调节pH至11-11.5，加活万籁 炭于75-80℃脱色半小时。压滤，冷至37-38℃，加入晶种放置结晶。冷至25℃过滤，结晶用蒸馏水洗涤，甩干，粉碎，于80℃左右干燥，得苯妥英钠。 | |
抗癫痫药及抗心律失常药。对癫痫大发作疗效好，对精神运动性发作和局限性发作次之，对小发作不但无效，甚至能诱发。 |
