1-(氯甲基)-4-硝基苯合成路线 （共 349 条）
反应条件
1: 71 percent / sodium ethoxide / ethanol / room temp. 4 h, reflux, 1 h 2: 96 percent / hydrogen / 5percent Pd/C / ethanol / Ambient temperature 3: 88 percent / H2SO4, NaNO3 / H2O / room temp., 20 min, 85 deg C, 35 min View Scheme
参考文献
Andreini; Biagi; Giorgi; Livi; Scartoni
Farmaco, 1989 , vol. 44, # 9 p. 831 - 841
参考文献
Pitts; Harrison; Moody
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 955 - 977
反应条件
hydrogenchloride; zinc
参考文献
Fischer,O.
Chemische Berichte, 1895 , vol. 28, p. 1340
参考文献
Rudolph
Patent: DE34234 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 15
反应条件
palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=80°C; 10 h; Inert atmosphere;
参考文献
Zhang, Wen-Wu; Zhang, Xing-Guo; Li, Jin-Heng
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5259 - 5264
反应条件
4 Angstroem MS; [Me(n-C8H17)3N]HSO4; sodium tungstate T=90°C; 10 h;
参考文献
Shi; Feng
Journal of Organic Chemistry, 2001 , vol. 66, # 9 p. 3235 - 3237
反应条件
sodium sulfite in methanol; water
参考文献
Auspex Pharmaceuticals, Inc.
Patent: US2008/103189 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
potassium hydroxide in water
T=50°C; 3 h; Green chemistry;
参考文献
Chen, Wen-Xin; Zhang, Cai-Yun; Shao, Li-Xiong
Tetrahedron, 2014 , vol. 70, # 4 p. 880 - 885
参考文献
Peacock
Journal of the Chemical Society, 1935 , p. 16
反应条件
in dimethyl sulfoxide; nitrobenzene
T=40°C; Rate constant;
参考文献
Litvinenko, L. M.; Shpan'ko, I. V.; Korostylev, A. P.
Doklady Chemistry, 1982 , vol. 266, p. 309 - 313
Dokl. Akad. Nauk SSSR Ser. Khim., 1982 , vol. 266, # 1 p. 131 - 134
