1-(氯甲基)-4-硝基苯合成路线 （共 349 条）
反应条件
pyridine in chloroform
参考文献
University of Alabama
Patent: US4006160 A1, 1977 ;
反应条件
potassium hydroxide in water
T=50°C; 3 h; Green chemistry;
参考文献
Chen, Wen-Xin; Zhang, Cai-Yun; Shao, Li-Xiong
Tetrahedron, 2014 , vol. 70, # 4 p. 880 - 885
反应条件
in tetrahydrofuran
T=20°C; benzylation;
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in chloroform
T=40 - 50°C;
参考文献
Xu, Cui-Lian; Chen, Zhen-Chu
Tetrahedron Letters, 1991 , vol. 32, # 25 p. 2933 - 2934
反应条件
nickel in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
Li, Hongbin; Wang, Hui; Pan, Yi; Shi, Yaozeng
Synthetic Communications, 1998 , vol. 28, # 3 p. 409 - 415
参考文献
Bristol-Myers Squibb Company
Patent: US5411969 A1, 1995 ;
反应条件
sodium acetate in ethanol
3 h; Heating;
参考文献
Ballini, Roberto; Marcantoni, Enrico; Petrini, Marino
Tetrahedron, 1989 , vol. 45, # 21 p. 6791 - 6798
参考文献
Sanchez, Ignacio H.; Aguilar, Maria Antonieta
Synthesis, 1981 , # 1 p. 55 - 56
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2009/131687 A2, 2009 ;
Location in patent: Page/Page column 146 ;
反应条件
1: Na / ethanol
2: aq. H2O2 / acetic acid
View Scheme
参考文献
Sammond, Douglas M.; Nailor, Kristen E.; Veal, James M.; Nolte, Robert T.; Wang, Liping; Knick, Victoria B.; Rudolph, Sharon K.; Truesdale, Anne T.; Nartey, Eldridge N.; Stafford, Jeffrey A.; Kumar, Rakesh; Cheung, Mui
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 15 p. 3519 - 3523
