1: With triethylamine in 1,2-dichloro-ethane
0.0166667 h;
2: With titanium tetrachloride in dichloromethane; 1,2-dichloro-ethane
T=20°C;
3: With water; sodium cyanoborohydride; sodium hydrogencarbonate
more than 3 stages;
参考文献
NOVARTIS AG
Patent: WO2008/63912 A1, 2008 ;
Location in patent: Page/Page column 73 ;
2.1: triethylamine; 1H-imidazole; thionyl chloride / dichloromethane / |Cooling with ice
2.2: |Cooling with ice
View Scheme
参考文献
Karanfil, Abdullah; Balta, Berrin; Eskici, Mustafa
Tetrahedron, 2012 , vol. 68, # 49 p. 10218 - 10229,12
Title/Abstract Full Text Show Details
Karanfil, Abdullah; Balta, Berrin; Eskici, Mustafa
Tetrahedron, 2012 , vol. 68, # 49 p. 10218 - 10229
Ignatchenko, A. V.; Terent'ev, P. B.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 3 p. 292 - 295
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 3 p. 348 - 351