1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-80°C; 0.25 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran T=-80°C; 0.5 h;
1: 4-pyridinecarbonitrile With sodium methylate in methanol T=20°C; 1 h; 2: Production of 2-cyanoisonicotinic acid hydrazide 1frac12; p-toluenesulfonic acid salt 24 h; reflux;
