1: ortho-dibromobenzene With magnesium in tetrahydrofuran
Inert atmosphere;
2: 2-pyridine carbonitrile in tetrahydrofuran
T=0°C; Inert atmosphere;
3: With hydrogenchloride; water in diethyl ether
0.5 h; Inert atmosphere;
1: piperidine With n-butyllithium in tetrahydrofuran; hexane
T=0 - 20°C; 0.25 h;
2: 2-pyridine carbonitrile With cesium fluoride in tetrahydrofuran; hexane
T=65°C; Further stages.;
参考文献
Penney, Jonathan M.
Tetrahedron Letters, 2004 , vol. 45, # 12 p. 2667 - 2669
