3-环丁基-9-(苯基甲基)-3,9-二氮杂螺[5.5]十一烷合成路线 (共 2 条)
反应条件
1: With acetic acid in dichloromethane T=0°C; 0.5 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C;
参考文献
NEUROGEN CORPORATION
Patent: WO2007/140383 A2, 2007 ;
Location in patent: Page/Page column 53 ;
WO 2007/140383 A2
反应条件
hydrogen; palladium(II) hydroxide/carbon in ethanol T=20°C; P=2585.81 Torr;
参考文献
US2008/247964 A1, ;
Page/Page column 29 ;
US 20080247964 A1