4,4-二甲基-1,3,2-二氧硫杂环己烷2-氧化物合成路线 （共 8 条）
反应条件
bis(1-methylethyl) ester of sulfurous acid; sodium t-butanolate in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
King, Steven A.; Pipik, Brenda; Conlon, David A.; Bhupathy
Synthetic Communications, 1997 , vol. 27, # 4 p. 701 - 707
参考文献
Szmant; Emerson
Journal of the American Chemical Society, 1956 , vol. 78, p. 454,457
参考文献
Szmant; Emerson
Journal of the American Chemical Society, 1956 , vol. 78, p. 454,457
反应条件
1: 66 percent / dimethylsulfoxide / 5 h / 120 °C 2: pyridine / 12 h / 0 °C 3: LiBr / dimethylsulfoxide / 3 h / 120 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 2975 - 2978
反应条件
1.1: dimethyl sulfoxide / 36 h / 100 °C 2.1: pyridine; thionyl chloride / 0 °C 3.1: diethyl ether / 2 h / Reflux 3.2: 3 h / Reflux View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913
反应条件
1.1: dimethyl sulfoxide / 36 h / 100 °C 2.1: pyridine; thionyl chloride / 0 °C 3.1: diethyl ether / 2 h / Reflux 3.2: 3 h / Reflux 4.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C 5.1: tetrahydrofuran / 10 - 15 °C 5.2: 0.33 h / 25 - 30 °C 6.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913
反应条件
1.1: dimethyl sulfoxide / 36 h / 100 °C
2.1: pyridine; thionyl chloride / 0 °C
3.1: diethyl ether / 2 h / Reflux
3.2: 3 h / Reflux
4.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913
反应条件
1.1: sodium periodate; ruthenium trichloride / dichloromethane; water; acetonitrile / 20 °C
2.1: N,N-dimethyl-formamide / 20 °C
2.2: 80 °C
View Scheme
参考文献
Sund, Christian; Belda, Oscar; Borkakoti, Neera; Lindberg, Jimmy; Derbyshire, Dean; Vrang, Lotta; Hamelink, Elizabeth; Hgren, Cathrine; Woestenenk, Esmeralda; Wikstroem, Kristina; Eneroth, Anders; Lindstroem, Erik; Kalayanov, Genadiy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6721 - 6727,7
