4-氨基-4'-硝基二苯基硫醚合成路线 （共 52 条）
反应条件
1: 80.4 percent / AcOH / tetrahydrofuran / 168 h / 20 °C 2: 80.2 percent / POCl3 / 0.67 h / Heating View Scheme
参考文献
Sun; Botros; Su; Kim; Wang; Baturay; Kwon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4160 - 4168
反应条件
potassium carbonate in dichloromethane Heating;
参考文献
Falzon, Cheryl L.; Ackermann, Uwe; Spratt, Neil; Tochon-Danguy, Henri J.; White, Jonathon; Howells, David; Scott, Andrew M.
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 12 p. 1089 - 1103
反应条件
sodium hydroxide in dichloromethane; water
参考文献
Bayer Aktiengesellschaft
Patent: US4771062 A1, 1988 ;
反应条件
1: T=50 - 85°C; 1 h; 2: With sodium tungstate; dihydrogen peroxide in water T=85°C; 4 h; 3: With hydrogenchloride in water 1 h; Heating / reflux;
参考文献
LUNDBECK PHARMACEUTICALS ITALY S.P.A.
Patent: WO2006/2690 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
1: acetic acid 2: potassium dichromate View Scheme
参考文献
Miura
Yakugaku Zasshi, 1942 , vol. 62, p. 224,225
Chem.Abstr., 1950 , p. 10161
反应条件
2: aqueous hydrogen peroxide; acetic acid 3: aqueous hydrochloric acid View Scheme
参考文献
Gabel'; Grinberg'
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1939 , vol. 12, p. 1481,1483
Chem.Abstr., 1940 , p. 6244
反应条件
acetic acid; zinc
anschliessenden Erhitzen des Reaktionsgemisches mit Acetylchlorid;
参考文献
Sasosow; Galtschenko
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1946 , vol. 19, p. 580,583, 584
Chem.Abstr., 1947 , p. 2703
反应条件
in chlorobenzene
T=90°C; 1 h; Product distribution; Further Variations:Temperaturesreaction times;
参考文献
Pilyugin; Valitov; Kiseleva; Kuznetsova; Mikhailyuk
Russian Journal of General Chemistry, 2003 , vol. 73, # 2 p. 244 - 248
参考文献
Gabel'; Grinberg'
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1939 , vol. 12, p. 1481,1483
Chem.Abstr., 1940 , p. 6244
反应条件
2: aqueous hydrogen peroxide; acetic acid / 100 °C
View Scheme
参考文献
Gabel'; Grinberg'
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1939 , vol. 12, p. 1481,1483
Chem.Abstr., 1940 , p. 6244
