(3S)-N-苄基-3-羟基吡咯烷-2,5-二酮合成路线 （共 20 条）
反应条件
acetyl chloride in ethanol T=50°C;
参考文献
Huang, Pei Qiang; Wang, Shi Li; Ye, Jian Liang; Ruan, Yuan Ping; Huang, You Qing; Zheng, Hong; Gao, Jing Xing
Tetrahedron, 1998 , vol. 54, # 41 p. 12547 - 12560
参考文献
Tamazawa, Kazuharu; Arima, Hideki; Koijma, Tadao; Isomura, Yasuo; Okada, Minoru; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2504 - 2511
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
1: 51 percent / ethanol / 3 h / 160 - 170 °C 2: 96 percent / pyridine, 4-dimethylaminopyridine (DMAP) / CH2Cl2 / Ambient temperature 3: phosphate buffer / dioxane / 2.5 h / 25 °C / lipase PS View Scheme
参考文献
Zheng, Jin-Li; Liu, Hui; Zhang, Yu-Feng; Zhao, Wei; Tong, Jin-Shuan; Ruan, Yuan-Ping; Huang, Pei-Qiang
Tetrahedron Asymmetry, 2011 , vol. 22, # 3 p. 257 - 263
反应条件
in dichloromethane T=20 - 25°C; 18 h; Cooling with ice;
参考文献
Bonanni, Marco; Manuelli, Massimo; Goti, Andrea; Faggi, Cristina; Cardona, Francesca
Arkivoc, 2013 , vol. 2014, # 3 p. 54 - 64
反应条件
lithium aluminium tetrahydride; hydrogen; acetic acid; palladium on activated charcoal 2.) 70 h, Parr hydrogenator; Multistep reaction;
参考文献
Bhat, Krishna L.; Flanagan, Denise M.; Joullie, Madeleine M.
Synthetic Communications, 1985 , vol. 15, # 7 p. 587 - 598
反应条件
lithium aluminium tetrahydride; hydrogen; acetic acid; palladium on activated charcoal 2.) 70 h, Parr hydrogenator; Multistep reaction;
参考文献
Bhat, Krishna L.; Flanagan, Denise M.; Joullie, Madeleine M.
Synthetic Communications, 1985 , vol. 15, # 7 p. 587 - 598
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bhat, Krishna L.; Flanagan, Denise M.; Joullie, Madeleine M.
Synthetic Communications, 1985 , vol. 15, # 7 p. 587 - 598
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bhat, Krishna L.; Flanagan, Denise M.; Joullie, Madeleine M.
Synthetic Communications, 1985 , vol. 15, # 7 p. 587 - 598
反应条件
1: boron trifluoride etherate, sodium borohydride / bis-(2-methoxy-ethyl) ether / 15 h / 100 °C 2: 1 h / 70 - 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 12 p. 2504 - 2511
