(4-溴苯胺亚甲基)丙二酸二乙酯合成路线 （共 13 条）
反应条件
Gould-Jacob reaction; 0.0416667 h; Irradiation;
参考文献
Dave, Chaitanya G.; Joshipura, Hardik M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 3 p. 650 - 652
反应条件
T=150°C; 3 h; Sealed tube;
参考文献
WO2010/133672 A1, ;
Page/Page column 22 ;
WO 2010/133672 A1
反应条件
bromine; acetic acid
参考文献
Journal of the Indian Chemical Society, , vol. 34, p. 817,819
参考文献
Journal of the Indian Chemical Society, , vol. 34, p. 817,819
反应条件
1: various solvent(s) / 1 h / Heating 2: aq. NaOH / 1 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
2: aqueous KOH 3: diphenyl ether 4: acetic acid; bromine View Scheme
参考文献
Schofield; Swain
Journal of the Chemical Society, 1950 , p. 384,389
反应条件
1: various solvent(s) / 1 h / Heating 2: aq. NaOH / 1 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
1: With trichlorophosphate T=180°C; 0.583333 h; Microwave irradiation; 2: With sodium hydroxide; water in dichloromethane
参考文献
ClanoTech AB
Patent: WO2009/63070 A2, 2009 ;
Location in patent: Page/Page column 13-14 ;
反应条件
2: aqueous KOH 3: diphenyl ether 4: phosphoryl chloride / 135 °C View Scheme
参考文献
Schofield; Swain
Journal of the Chemical Society, 1950 , p. 384,389
反应条件
in diphenylether T=250°C; 0.0833333 h; microwave irradiation;
参考文献
WO2009/40377 A2, ;
Page/Page column 19 ;
