2-氨基-3-甲氧基吡啶合成路线 （共 16 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate 3 h;
参考文献
Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng
Patent: US2013/210818 A1, 2013 ;
Location in patent: Paragraph 0380 ;
反应条件
copper acetylacetonate; potassium phosphate; ammonia in N,N-dimethyl-formamide T=90°C; 24 h; GloveboxAutoclave; chemoselective reaction;
参考文献
Fantasia, Serena; Windisch, Johannes; Scalone, Michelangelo
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 627 - 631
反应条件
methanol in diethyl ether T=20°C; Methylation;
参考文献
Trapani, Giuseppe; Franco, Massimo; Latrofa, Andrea; Ricciardi, Laura; Carotti, Angelo; Serra, Mariangela; Sanna, Enrico; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3934 - 3941
反应条件
in methanol; benzene
反应条件
1: sulfuric acid; nitric acid 2: iron-powder; acetic acid View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 74, p. 1171,1174
反应条件
1: 150 - 160 °C 2: sulfuric acid; nitric acid 3: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Journal of the American Chemical Society, , vol. 69, p. 1147,1148
参考文献
Tetrahedron Letters, , vol. 26, # 21 p. 2571 - 2574
反应条件
1: With bromine in acetic acid T=20°C; 16.5 h; 2: With sodium hydrogencarbonate in water T=0°C; pH=7;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 97 percent / dioxane 2: 78 percent / NH2OH; DMAP / methanol; ethanol View Scheme
参考文献
Nettekoven, Matthias; Puellmann, Bernd; Schmitt, Sebastien
Synthesis, 2003 , # 11 p. 1649 - 1652
反应条件
1.1: bromine / acetic acid / 16.5 h / 20 °C 1.2: 0 °C / pH 7 2.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 2.2: 1 h / 20 °C / pH 13 3.1: methanol / 3 h / 75 °C View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
