2-甲氨基-5-氯二苯甲酮合成路线 （共 61 条）
反应条件
1: 1) SOCl2 / 1) HMPA, MeCN, 15 min, 2) ether, -5 deg C - 0 deg C, 2 h 2: 1) NaH / 1) THF, -5 deg C, 30 min, 2) -5 deg C - RT, then 2 h 3: 73 percent / N2H4*H2O / CHCl3; ethanol / 12 h / Ambient temperature 4: 2.8 percent / methanol / 144 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 22 p. 4489 - 4493
反应条件
hydrazine hydrate in ethanol; chloroform 12 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 46, # 22 p. 4489 - 4493
参考文献
Journal of Organic Chemistry, , vol. 46, # 22 p. 4489 - 4493
反应条件
hydrogenchloride in methanol; water T=80°C; 840 h; Title compound not separated from byproducts;
参考文献
Nudelman, N. Sbarbati; Waisbaum, R. G. de
Journal of Physical Organic Chemistry, 1997 , vol. 10, # 2 p. 97 - 106
反应条件
hydrogenchloride; ammonia; water in methanol Hydrolysis; 18 h; Heating;
参考文献
Markovic, Dean; Hamersak, Zdenko; Visnjevac, Aleksandar; Kojic-Prodic, Biserka; Sunjic, Vitomir
Helvetica Chimica Acta, 2000 , vol. 83, # 3 p. 603 - 615
反应条件
1: 1) NaH / 1) THF, -5 deg C, 30 min, 2) -5 deg C - RT, then 2 h 2: 73 percent / N2H4*H2O / CHCl3; ethanol / 12 h / Ambient temperature 3: 2.8 percent / methanol / 144 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 22 p. 4489 - 4493
反应条件
hydrogenchloride 10 h; Heating;
参考文献
Schleuder, M.; Butzki, Susanne; Richter, P.; Sokolov, A.
Pharmazie, 1987 , vol. 42, # 1 p. 54 - 55
反应条件
hydrogenchloride in water T=80°C; 840 h; Title compound not separated from byproducts;
参考文献
Nudelman, N. Sbarbati; Waisbaum, R. G. de
Journal of Physical Organic Chemistry, 1997 , vol. 10, # 2 p. 97 - 106
反应条件
1: 73 percent / N2H4*H2O / CHCl3; ethanol / 12 h / Ambient temperature 2: 2.8 percent / methanol / 144 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 22 p. 4489 - 4493
反应条件
1: 1) NaH / 1) THF, 0 to -8 deg C, 30 min, 2) 0 - -8 deg C to RT, then 1.5 h 2: 2.1 percent / N2H4*H2O / CHCl3; ethanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 22 p. 4489 - 4493
