3-反-溴碳-2,2'-二甲基氧酸酯合成路线 （共 39 条）
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane
T=60°C; 1 h;
2: (4S)-2,2-dimethyl-4-formyl-3-oxazolidine-carboxylic acid tert-butyl ester in tetrahydrofuran; hexane
T=-78°C; 12 h;
参考文献
Isis Innovation Limited
Patent: US2007/142632 A1, 2007 ;
Location in patent: Page/Page column 27 ;
反应条件
Wilkinson's catalyst; triphenylphosphine; isopropyl alcohol in tetrahydrofuran
T=25°C; 4 h;
参考文献
Lebel, Helene; Paquet, Valerie
Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 320 - 328
反应条件
potassium tert-butylate in tetrahydrofuran
T=0°C; Wittig olefination;
参考文献
Radha Krishna, Palakodety; Dayaker
Tetrahedron Letters, 2007 , vol. 48, # 41 p. 7279 - 7282
反应条件
1: -30 - 0 °C / pH 15
2: aq. AcOH / 5 h / 50 °C
View Scheme
参考文献
Suzuki, Hikokazu; Mori, Michiko; Shibakami, Motonari
Synlett, 2003 , # 14 p. 2163 - 2166
反应条件
1: pentadec-1-yne With Schwartz's reagent in tetrahydrofuran
T=20°C; 1 h;
2: (4S)-2,2-dimethyl-4-formyl-3-oxazolidine-carboxylic acid tert-butyl ester With zinc dibromide in tetrahydrofuran
T=20°C; 24 h;
3: With acetic acid in water
T=50°C; 5 h;
参考文献
Murakami, Teiichi; Furusawa, Kiyotaka
Tetrahedron, 2002 , vol. 58, # 45 p. 9257 - 9263
反应条件
potassium carbonate
T=0 - 23°C; 14 h; Inert atmosphere;
参考文献
Wzorek, Joseph S.; Knoepfel, Thomas F.; Sapountzis, Ioannis; Evans, David A.
Organic Letters, 2012 , vol. 14, # 23 p. 5840 - 5843
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-Acetylaminobenzenesulfonyl Azide; potassium carbonate in chloroform
T=0°C; Seyferth-Gilbert homologation; 48 h;
2: (4S)-2,2-dimethyl-4-formyl-3-oxazolidine-carboxylic acid tert-butyl ester With potassium carbonate in methanol; chloroform
T=0°C; Seyferth-Gilbert homologation; 24 h;
参考文献
Ayed, Charfedinne; Picard, Julien; Lubin-Germain, Nadege; Uziel, Jacques; Auge, Jacques
Science China Chemistry, 2010 , vol. 53, # 9 p. 1921 - 1926
反应条件
1: 1.) PPh3, 2.) Et3N / 1) CH2Cl2, -20 deg C, 30 min; 2) CH2Cl2, -60 deg C, 30 min, rt, overnight
2: 79 percent / BuLi / tetrahydrofuran / 1) -78 deg C, 30 min; 2) -15 deg C, 15 min
View Scheme
参考文献
Falorni, Massimo; Giacomelli, Giampaolo; Spanu, Emanuela
Tetrahedron Letters, 1998 , vol. 39, # 50 p. 9241 - 9244
反应条件
ethylmagnesium bromide; triphenylphosphine
THF; Multistep reaction;
参考文献
Cameron, Stuart; Khambay, Bhupinder P.S.
Tetrahedron Letters, 1998 , vol. 39, # 14 p. 1987 - 1990
