2,2-二甲基-3-丁烯酸合成路线 （共 52 条）
反应条件
1: 1-chloro-3-methyl-2-butene With iodine; magnesium in tetrahydrofuran T=20°C; RefluxInert atmosphere; 2: carbon dioxide in tetrahydrofuran Inert atmosphere;
参考文献
Organic Letters, , vol. 13, # 5 p. 1080 - 1082
反应条件
sodium hydroxide in ethanol T=20°C; 16 h;
参考文献
Journal of Organic Chemistry, , vol. 65, # 24 p. 8402 - 8405
反应条件
1: With [Pd(OSO2CF3)(CH3Si(C6H4P(C6H5)2)2)]; triethylaluminum in N,N-dimethyl-formamide; toluene T=20°C; 48 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide; toluene
参考文献
Journal of the American Chemical Society, , vol. 130, # 46 p. 15254 - 15255
反应条件
n-butyllithium; diethylamine in tetrahydrofuran; hexane 1.) -78 deg C, 0.5 h, 2.) room temp., 1 h;
参考文献
Tetrahedron, , vol. 54, # 17 p. 4357 - 4366
反应条件
1: With [Cu(N,N′-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene)Cl]; potassium tert-butylate in tetrahydrofuran T=70°C; 16 h; Inert atmosphereSealed tube; 2: With hydrogenchloride in tetrahydrofuran Inert atmosphereSealed tube; regioselective reaction;
参考文献
Organic Letters, , vol. 15, # 15 p. 4034 - 4037
反应条件
lithium diisopropyl amide in tetrahydrofuran T=0°C;
参考文献
Synlett, , # 7 p. 789 - 791
反应条件
1: With [Cu(N,N′-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene)Cl]; potassium tert-butylate in tetrahydrofuran T=70°C; 16 h; Inert atmosphereSealed tube; 2: With hydrogenchloride in tetrahydrofuran Inert atmosphereSealed tube; regioselective reaction;
参考文献
Organic Letters, , vol. 15, # 15 p. 4034 - 4037
反应条件
1: 3-chloro-3-methyl-1-butene With magnesium in tetrahydrofuran Inert atmosphereReflux; 2: carbon dioxide in tetrahydrofuran 2 h; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 26 p. 4405 - 4411
反应条件
1: 88 percent / pyridine / 48 h / 20 °C 2: 96 percent / DBU / 3 h / 140 °C 3: 99 percent / NaOH / ethanol / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 24 p. 8402 - 8405
