反应条件
1: With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 2 h;
2: With N,N,N',N,-tetramethylethylenediamine in diethyl ether; pentane
T=-78 - 25°C;
3: With water; ammonium chloride in diethyl ether; pentane
参考文献
ASTRAZENECA AB; HOLENZ, Joerg; KARLSTROeM, Sofia; KIHLSTROeM, Jacob; KOLMODIN, Karin; LINDSTROeM, Johan; RAKOS, Laszlo; ROTTICCI, Didier; SWAHN, Britt-Marie; VON BERG, Stefan
Patent: WO2011/2409 A1, 2011 ;
Location in patent: Page/Page column 43-44 ;
WO 2011/002409 A1