ammonium chloride in tetrahydrofuran; methanol; water
To a stirred soln. of Me3SnCu*Me2S in THF (Ar, -78°C) was added sequentially a THF soln. of the 1-alkyne and CH3OH. The mixt. was stirred(10 min) and then at -63°C (12 h). Satd. aq. NH4Cl and ether were added; allowed to warm to room temp.; Aq. phase was extd. with ether. The org. exts. were washed (satd. aq. NH4Cl) and dried (MgSO4). Removal of the solvent; column chromy. (silica gel) followed by distillation. (E)-1-trimethylstannyl-1-alkene not isolated, detected by gas-liq. chromy..;
参考文献
Piers, Edward; Chong, J. Michael
Canadian Journal of Chemistry, 1988 , vol. 66, p. 1425 - 1429
magnesium
T=600°C; P=0.01 - 0.1 Torr; Further byproducts given;
参考文献
Aitken, R. Alan; Hodgson, Philip K.G.; Morrison, John J.; Oyewale, Adebayo O.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 402 - 415
