反应条件
1: 51 percent / dihydroquinidine 4-chlorobenzoate, N-methylmorpholine N-oxide / OsO4 / acetone; H2O; toluene / 1 h / -7 °C 2: 88 percent / triethylamine / CH2Cl2 / 63 h / 0 °C 3: 91 percent / K2CO3 / dimethylformamide; H2O / 24 h / 20 °C 4: 95 percent / NaN3 / methanol; H2O; methyl formate / 46 h / 50 °C 5: 1.) triethylamine, 4-(dimethylamino)pyridine, 2.) H2 / 2.) Pd-C / 1a.) ethyl acetate, 20 deg C, 4h, 1b.) MeOH, 3h, 2.) 68h View Scheme
参考文献
Afon'Kin; Kostrikin; Shumeiko; Popov; Matveev; Matvienko; Zabudkin
Russian Chemical Bulletin, 2012 , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., 2012 , # 11 p. 2132 - 2145,14
