4-(氯甲基)-1-(三苯基甲基)-1H-咪唑合成路线 （共 7 条）
反应条件
thionyl chloride in dichloromethane T=0 - 20°C;
参考文献
Houssin, Raymond; Pommery, Jean; Salauen, Marie-Catherine; Deweer, Sophie; Goossens, Jean-Francois; Chavatte, Philippe; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 533 - 536
反应条件
1: 59 percent / CH2Cl2 / 18 h / 20 °C 2: 81 percent / SOCl2 / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Peng, Hairuo; Carrico, Dora; Thai, Van; Blaskovich, Michelle; Bucher, Cynthia; Pusateri, Erin E.; Sebti, Said M.; Hamilton, Andrew D.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1768 - 1784
反应条件
1: phosphonic acid diethyl ester With lithium hexamethyldisilazane in tetrahydrofuran T=-70°C; 2: 4-(chloromethyl)-1-(triphenylmethyl)-1H-imidazole in tetrahydrofuran T=-70 - 25°C; Michaelis-Becker reaction;
参考文献
Azwell Inc.
Patent: EP1477487 A1, 2004 ;
Location in patent: Page 7-8 ;
EP 1477487 A1
反应条件
sodium iodide; triethyl phosphite in acetonitrile
参考文献
Merck and Co., Inc.
Patent: US5965578 A1, 1999 ;
US 5965578 A
反应条件
in N,N-dimethyl-formamide T=80°C; 16 h; Under argon;
参考文献
Azwell Inc.
Patent: EP1477487 A1, 2004 ;
Location in patent: Page 8 ;
EP 1477487 A1
反应条件
n-butyllithium; ammonia; diisopropylamine in tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate
参考文献
Schering Corporation
Patent: US5807872 A1, 1998 ;
反应条件
in tetrahydrofuran Ambient temperature;
参考文献
Cordi; Snyers; Giraud-Mangin; Van der Maesen; Van Hoeck; Beuze; Ellens; Napora; Gillet; Gorissen; Calderon; Remacle; Janssens de Varebeke; Van Dorsser; Roba
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 557 - 568
