S-(-)-2-N-BOC-3-环己基-1-丙醇合成路线 （共 13 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C;
参考文献
VITAE PHARMACEUTICALS, INC.
Patent: WO2009/154766 A1, 2009 ;
Location in patent: Page/Page column 54 ;
WO 2009/154766 A1
反应条件
borane in tetrahydrofuran
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 4 p. 468 - 478
反应条件
5 rhodium-on-charcoal; hydrogen in methanol; water T=60°C; P=2828.7 - 3087.28 Torr; 16 h;
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
hydrogen; {(1,5-cyclooctadiene)Rh(1,2-bis((2S,5S)-2,5-diethylphospholano)benzene)}triflate in tetrahydrofuran T=20 - 25°C; Catalytic hydrogenation; P=1551.44 Torr; 12 h;
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
sodium hydrogencarbonate; acetic acid; citric acid in tetrahydrofuran; methanol; diethyl ether
参考文献
EP396065 A1, ;
EP 0396065 A1
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran; ethanol T=-5°C; 5 h;
参考文献
Journal of Organic Chemistry, , vol. 52, # 8 p. 1487 - 1492
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
triethylamine in N,N-dimethyl-formamide a) 0 deg C, 30 min, b) RT, 2 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 7 p. 1259 - 1266
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: NaBH4 / H2O / 0 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
