3,4,5,6,7,8-六氢-2(1H)-喹啉酮合成路线 （共 16 条）
反应条件
hydrogen; PtO2 in acetic acid; ethyl acetate
参考文献
Bonjouklian, Rosanne; Cohen, Jeffrey Daniel; Gruber, Joseph Michael; Johnson, Douglas Webb; Jungheim, Louis Nickolaus; Kroin, Julian Stanley; Lander, Peter Ambrose; Lin, Ho-Shen; Lohman, Mark Christopher; Muehl, Brian Stephen; Norman, Bryan Hurst; Patel, Vinod Francis; Richett, Michael Enrico; Thrasher, Kenneth Jeff; Vepachedu, Sreenivasarao; White, Wesley Todd; Xie, Yongping; York, Jeremy Schulenburg; Parkhurst, Brandon Lee
Patent: US2003/100576 A1, 2003 ;
US 20030100576 A1
反应条件
water; dihydridotetrakis(triphenylphosphine)ruthenium(II) in ethylene glycol dimethyl ether
T=120°C; 24 h;
参考文献
Murahashi, Shun-Ichi; Sasao, Shigehiro; Saito, Eiichiro; Naota, Takeshi
Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2521 - 2523
反应条件
cyclohexylamine; hydroquinone in acetic acid
T=200°C; 5 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/14916 A2, 2006 ;
Location in patent: Page/Page column 12 ;
反应条件
water; dihydridotetrakis(triphenylphosphine)ruthenium(II) in ethylene glycol dimethyl ether
T=120°C; 24 h;
参考文献
Murahashi, Shun-Ichi; Sasao, Shigehiro; Saito, Eiichiro; Naota, Takeshi
Tetrahedron, 1993 , vol. 49, # 39 p. 8805 - 8826
反应条件
aluminium trichloride in 1,4-dioxane
T=90°C; 6 h;
参考文献
Barluenga, Jose; Muniz, Laudina; Palacios, Francisco; Gotor, Vicente
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 65 - 67
反应条件
1: 2.) water / 1.) 1,4-dioxane, reflux, 14 h, 2.) reflux, 1 h
2: 72 percent / water / RuH2(PPh3)4 / 1,2-dimethoxy-ethane / 24 h / 120 °C
View Scheme
参考文献
Murahashi, Shun-Ichi; Sasao, Shigehiro; Saito, Eiichiro; Naota, Takeshi
Tetrahedron, 1993 , vol. 49, # 39 p. 8805 - 8826
反应条件
aluminum oxide; 1-amino-2,4,6-trichlorobenzene in chloroform
T=120°C; 7 h;
参考文献
Kayukova, L. A.; Chernova, N. V.; Manchuk, Z. N.; Erzhanov, K. B.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 8.1 p. 1389 - 1392
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 8 p. 1608 - 1612
反应条件
aluminum oxide in chloroform
T=120°C; 7 h; Title compound not separated from byproducts;
参考文献
Kayukova, L. A.; Chernova, N. V.; Manchuk, Z. N.; Erzhanov, K. B.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 8.1 p. 1389 - 1392
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 8 p. 1608 - 1612
反应条件
1: 100 percent / methanolic NH3 / methanol / 24 h / 125 °C
2: 57.58 percent / CH3COOH / 45 h / 20 °C
View Scheme
参考文献
Srivastava; Kumar; Singh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 12 p. 1248 - 1250
反应条件
methanol; magnesium
Ambient temperature;
参考文献
Brettle, Roger; Shibib, Sa'ad M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2912 - 2919
