(2E)-3-(4-溴-2-噻吩基)丙烯酸合成路线 （共 8 条）
反应条件
piperidine; pyridine T=100°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 1 p. 250 - 254
反应条件
malonic acid in pyridine
反应条件
1: 90 percent / Br2; AlCl3 / CH2Cl2 2: 96 percent / piperidine / pyridine / 22 h / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1167 - 1171
反应条件
1: 75 percent / DPPA; Et3N / tetrahydrofuran / 20 °C 2: toluene / 120 °C 3: 48 percent / I2 / 1,2-dichloro-benzene / 170 °C View Scheme
参考文献
Betschmann, Patrick; Burchat, Andrew F.; Calderwood, David J.; Curtin, Michael L.; Davidsen, Steven K.; Davis, Heather M.; Frey, Robin R.; Heyman, Howard R.; Hirst, Gavin C.; Hrnciar, Peter; Michaelides, Michael R.; Muckey, Melanie A.; Rafferty, Paul; Wada, Carol K.
Patent: US2005/26944 A1, 2005 ;
反应条件
1: 75 percent / DPPA; Et3N / tetrahydrofuran / 20 °C 2: toluene / 120 °C 3: 48 percent / I2 / 1,2-dichloro-benzene / 170 °C 4: 100 percent / POCl3 / 120 °C 5: 57 percent / aq. NH3 / dioxane / 150 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 1 p. 250 - 254
反应条件
1: 75 percent / DPPA; Et3N / tetrahydrofuran / 20 °C 2: toluene / 120 °C 3: 48 percent / I2 / 1,2-dichloro-benzene / 170 °C 4: 100 percent / POCl3 / 120 °C View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: 75 percent / DPPA; Et3N / tetrahydrofuran / 20 °C
2: toluene / 120 °C
3: 48 percent / I2 / 1,2-dichloro-benzene / 170 °C
4: 66 percent / NIS / tetrahydrofuran; dimethylformamide / 40 °C
5: 100 percent / POCl3 / 120 °C
6: 50 percent / aq. NH3 / dioxane / 150 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
反应条件
1: 75 percent / DPPA; Et3N / tetrahydrofuran / 20 °C
2: toluene / 120 °C
3: 48 percent / I2 / 1,2-dichloro-benzene / 170 °C
4: 66 percent / NIS / tetrahydrofuran; dimethylformamide / 40 °C
5: 100 percent / POCl3 / 120 °C
6: 50 percent / aq. NH3 / dioxane / 150 °C
7: 53 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 80 °C
View Scheme
参考文献
Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254
