[1,4'-联哌啶]-1'-甲酰氯合成路线 (共 4 条)
反应条件
1: in dichloromethane; acetonitrile T=20 - 70°C; 2: With potassium carbonate in dichloromethane T=20°C;
参考文献
CADILA HEALTHCARE LIMITED
Patent: EP2341046 A2, 2011 ;
Location in patent: Page/Page column 9 ;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1446 - 1454
反应条件
pyridine; acetamide; triethylamine in dichloromethane T=30 - 40°C; 2 h; Inert atmosphere; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: EP2341046 A2, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
1: triethylamine; pyridine; acetamide / dichloromethane / 2 h / 30 - 40 °C / Inert atmosphere 2: hydrogenchloride / water View Scheme
参考文献
CADILA HEALTHCARE LIMITED
Patent: EP2341046 A2, 2011 ;