9-(3-O-乙酰基-5-O-苯甲酰基-2-脱氧-2-氟-beta-D-阿拉伯糖呋喃基)-2,6-二氯-9H-嘌呤合成路线 （共 5 条）
反应条件
1: 72 percent / aq. NaN3 / ethanol / 0.5 h / Heating 2: 80 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr 3: 91 percent / aq. NaOH / methanol / 19 h / Ambient temperature 4: 58 percent / H2O / 19 h / Ambient temperature; adenosine deaminase type I View Scheme
参考文献
Montgomery; Shortnacy; Carson; Secrist III
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2389 - 2392
反应条件
ammonia in ethanol 72 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Montgomery, John A.; Shortnacy-Fowler, Anita T.; Clayton, Sarah D.; Riordan, James M.; Secrist, John A.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 397 - 401
反应条件
lithium hydroxide; ammonia 1.) ethanol, RT, 3 d, 2.) acetonitrile, RT, 3 h; Yield given. Multistep reaction;
参考文献
Montgomery, John A.; Shortnacy-Fowler, Anita T.; Clayton, Sarah D.; Riordan, James M.; Secrist, John A.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 397 - 401
反应条件
With sodium azide in ethanol 0.5 h; Heating;
参考文献
Montgomery; Shortnacy; Carson; Secrist III Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2389 - 2392
反应条件
Multi-step reaction with 2 steps 1: 72 percent / aq. NaN3 / ethanol / 0.5 h / Heating2: 80 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr
参考文献
Montgomery; Shortnacy; Carson; Secrist III Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2389 - 2392
