6-甲基-6-庚烯-2-酮合成路线 （共 52 条）
反应条件
zinc copper in ethanol; water
2 h; sonication;
参考文献
Singh, Vasundhara; Chaudhary, Sangeeta; Sapehiyia, Varinder; Kaur, Irvinder; Kad, Goverdhan Lal; Singh, Jasvinder
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1950 - 1953
反应条件
1: 86 percent / pyridinium chlorochromate, sodium acetate / CH2Cl2 / 0.75 h / 25 °C
2: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
3: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
4: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
5: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
6: 97 percent / pyridine
7: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
2: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
3: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
4: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
5: 97 percent / pyridine
6: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 1.) p-CH3C6H4SO3H, 2.) LAH / 1.) C6H6
2: 86 percent / pyridinium chlorochromate, sodium acetate / CH2Cl2 / 0.75 h / 25 °C
3: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
4: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
5: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
6: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
7: 97 percent / pyridine
8: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
2: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
3: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
4: 97 percent / pyridine
5: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
参考文献
Meinwald; Yankeelov
Journal of the American Chemical Society, 1958 , vol. 80, p. 5266,5269
反应条件
sodium hydrogencarbonate; dibenzoyl peroxide
24 h; Heating;
参考文献
Bugarcic, Zorica M.; Mojsilovic, Biljana; Marjanovic, Ljiljana; Konstantinovic, Stanimir
Monatshefte fur Chemie, 2000 , vol. 131, # 10 p. 1091 - 1096
反应条件
1.1: (iPr)2NLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: tetrahydrofuran; hexane / 20 °C
2.1: NaIO4; phosphate buffer / H2O / 20 °C / pH 7.0
View Scheme
参考文献
Tokuyasu, Takahiro; Masuyama, Araki; Nojima, Masatomo; McCullough, Kevin J.
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1069 - 1075
反应条件
2: 1) n-BuLi, HMPA / 1) THF, hexane, 30 min, -78 deg C, 2) THF, to r.t., overnight
3: 86 percent / sodium periodate / methanol / 25 °C / other solvent: phosphate buffer (pH 7)
View Scheme
参考文献
Trehan, I. R.; Kad, G. L.; Gupta, Sangita
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1243 - 1244
参考文献
Albisetti et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 2637,2641
