DL-4-氯-3-羟基丁酸乙酯合成路线 （共 23 条）
反应条件
1: With t-butylmagnesium chloride in tetrahydrofuran; toluene T=0 - 5°C; 1 h; 2: With lithium diisopropyl amide in tetrahydrofuran; hexane; toluene T=5°C; 19 h;
参考文献
Kaneka Corporation
Patent: US6340767 B1, 2002 ;
Location in patent: Example 5 ;
反应条件
1: With sodium tetrahydroborate in methanol; toluene T=20°C; 12 h; 2: With hydrogenchloride; water in methanol; toluene T=10°C;
参考文献
WO2008/93955 A1, ;
Paragraph 63-64 ;
反应条件
sodium iodide in acetone
T=58 - 60°C; 120 h;
参考文献
LEK Pharmaceuticals d.d.
Patent: EP1775299 A1, 2007 ;
Location in patent: Page/Page column 13; 16-17 ;
