丙二酸二乙酯合成路线

VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CACATIAN, Salvacion; CLAREMON, David, A.; DILLARD, Lawrence, W.; FUCHS, Klaus; HEINE, Niklas; JIA, Lanqi; LEFTHERIS, Katerina; MCKEEVER, Brian; MORALES-RAMOS, Angel; SINGH, Suresh; VENKATRAMAN, Shankar; WU, Guosheng; WU, Zhongren; XU, Zhenrong; YUAN, Jing; ZHENG, Yajun
Patent: WO2010/105179 A2, 2010 ;
Location in patent: Page/Page column 76 ;
WO 2010/105179 A2

589-15-1对溴溴苄+

105-53-3丙二酸二乙酯

70146-78-0

参考文献

Musso, David L.; Cochran, Felicia R.; Kelley, James L.; McLean, Ed W.; Selph, Jeffrey L.; Rigdon, Greg C.; Orr, G. Faye; Davis, Ronda G.; Cooper, Barrett R.; Styles, Virgil L.; Thompson, James B.; Hall, William R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 399 - 408

589-17-34-溴苄氯+

105-53-3丙二酸二乙酯

70146-78-0

参考文献

Ward, Richard A.; Brassington, Claire; Breeze, Alexander L.; Caputo, Alessandro; Critchlow, Susan; Davies, Gareth; Goodwin, Louise; Hassall, Giles; Greenwood, Ryan; Holdgate, Geoffrey A.; Mrosek, Michael; Norman, Richard A.; Pearson, Stuart; Tart, Jonathan; Tucker, Julie A.; Vogtherr, Martin; Whittaker, David; Wingfield, Jonathan; Winter, Jon; Hudson, Kevin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3285 - 3306

105-53-3丙二酸二乙酯

70146-78-0

参考文献

Huang, Wen; Hong, Longcheng; Zheng, Pengzhi; Liu, Ruiting; Zhou, Xigeng
Tetrahedron, 2009 , vol. 65, # 18 p. 3603 - 3610

1194-98-5+

105-53-3丙二酸二乙酯

70160-51-9

参考文献

Cerqueira, Nuno M. F. S. A.; Rodrigues, Ligia M.; Oliveira-Campos, Ana M. F.; Melo de Carvalho, Luis H.; Coelho, Paulo J.; Dubest, Roger; Aubard, Jean; Samat, Andre; Guglielmetti, Robert
Helvetica Chimica Acta, 2003 , vol. 86, # 9 p. 3244 - 3253

13176-46-04-溴乙酰乙酸乙酯+

105-53-3丙二酸二乙酯

70184-67-7

参考文献

Kato; Kimura; Tanji
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 12 p. 3880 - 3883