1: 4-bromo-phenol With di-isopropyl azodicarboxylate; triphenylphosphine; Wang resin in tetrahydrofuran
T=20°C;
2: 2,5-dichloro-phenylboronic acid With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=80°C; Suzuki reaction;
3: With trifluoroacetic acid in dichloromethane
0.166667 h;
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2: nickel dichloride; triphenylphosphine; bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane / tetrahydrofuran / 16 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
Marquez, Irene R.; Miguel, Delia; Millan, Alba; Marcos, M. Luisa; De Cienfuegos, Luis Alvarez; Campana, Araceli G.; Cuerva, Juan M.
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1529 - 1541
