2,6-二氨基-4,5,6,7-四氢苯并噻唑合成路线 （共 15 条）
反应条件
2: 90 percent / triethylamine / tetrahydrofuran / 2 h / -5 °C 3: borane-tetrahydrofuran complex / tetrahydrofuran / 1 h / 50 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SAHADEVA REDDY, Maramreddy
Patent: WO2011/21214 A2, 2011 ;
反应条件
2: 84 percent / triethylamine / tetrahydrofuran / 2 h / -5 °C 3: borane-tetrahydrofuran complex / tetrahydrofuran / 1 h / 50 °C View Scheme
参考文献
Schneider, Claus S.; Mierau, Joachim
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 494 - 498
参考文献
Prasanna; Kavitha; Raghava; Vinaya; Ranganatha; Raghavan, Sathees C.; Rangappa
Investigational New Drugs, 2010 , vol. 28, # 4 p. 454 - 465
反应条件
optical resolution with chiral tartaric acid;
参考文献
AMR TECHNOLOGY, INC.
Patent: WO2006/12276 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
反应条件
2: 90 percent / triethylamine / tetrahydrofuran / 2 h / -5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498
