2-(4-溴苯基)-1,3-二氧戊环合成路线 （共 37 条）
反应条件
1: Pd(PPh3)4, triethylamine
2: H(+), water
View Scheme
参考文献
Issleib, K.; Doepfer, K.-P.; Balszuweit, A.
Phosphorus and Sulfur and the Related Elements, 1982 , vol. 14, p. 171 - 178
反应条件
1: 1.) Mg, 2.) PCl3 / 1.) THF, 2.) r.t., 12 h; reflux, 3 h
2: 55 percent / 2 N aq. HCl / tetrahydrofuran / 0.25 h / Heating
View Scheme
参考文献
Chalier, Florence; Berchadsky, Yves; Finet, Jean-Pierre; Gronchi, Gerard; Marque, Sylvain; Tordo, Paul
Journal of Physical Chemistry, 1996 , vol. 100, # 10 p. 4323 - 4330
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine
参考文献
Issleib, K.; Doepfer, K.-P.; Balszuweit, A.
Phosphorus and Sulfur and the Related Elements, 1982 , vol. 14, p. 171 - 178
反应条件
Yield given. Multistep reaction;
参考文献
Gloyna, Dieter; Henning, Hans-Georg; Voicu, Tino
Zeitschrift fuer Chemie (Stuttgart, Germany), 1980 , vol. 20, # 7 p. 258 - 259
反应条件
1: 2-(4'-bromophenyl)-1,3-dioxolane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: (4-morpholinyl)methanone in tetrahydrofuran; hexane
T=-78°C; 3 h;
3: With water in tetrahydrofuran; diethyl ether; hexane
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 128 ;
反应条件
triethylsilane; palladium diacetate; sodium carbonate; 1,4-di(diphenylphosphino)-butane in N,N-dimethyl-formamide
T=85°C; Inert atmosphereSealed tube;
参考文献
Ueda, Tsuyoshi; Konishi, Hideyuki; Manabe, Kei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8611 - 8615
Angew. Chem., 2013 , vol. 125, # 33 p. 8773 - 8777,5
反应条件
[bis(acetoxy)iodo]benzene; water; lithium bromide
T=20°C; 0.25 h;
参考文献
Panchan, Waraporn; Chiampanichayakul, Supanimit; Snyder, Deanna L.; Yodbuntung, Siriporn; Pohmakotr, Manat; Reutrakul, Vichai; Jaipetch, Thaworn; Kuhakarn, Chutima
Tetrahedron, 2010 , vol. 66, # 14 p. 2732 - 2735
