N-(苯基甲基)-d-丝氨酸合成路线 （共 10 条）
反应条件
1: With sodium hydroxide; water in methanol T=15 - 22°C; 1.75 h; 2: With hydrogenchloride in water T=5°C; pH=6.5; 25 h;
参考文献
WO2005/58245 A2, ;
Page/Page column 28-29 ;
WO 2005/058245 A2
反应条件
C24H29CoN2O4 in dichloromethane; water T=10°C; 24 h; Resolution of racemate; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 7 p. 1253 - 1264
反应条件
potassium carbonate in water T=20°C; Alkylation; 25 h;
参考文献
Synthetic Communications, , vol. 30, # 11 p. 1911 - 1915
反应条件
sodium cyanoborohydride in methanol 18 h; Ambient temperature;
参考文献
Chemistry Letters, , p. 441 - 444
反应条件
1: With sodium hydroxide in water Large scale reaction; 2: With sodium tetrahydroborate in water T=5 - 15°C; Large scale reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 21 p. 6527 - 6530
参考文献
Helvetica chimica acta, , vol. 51, # 1 p. 78 - 85
反应条件
1: (i) Na2SO4, (ii) H2, Raney-Ni 2: aq. HCl View Scheme
参考文献
Helvetica chimica acta, , vol. 51, # 1 p. 78 - 85
反应条件
1: 23 percent / sodium hydroxide / H2O / 0 deg C, 30 min, 30-33 deg C, 2 h 2: 65 percent / pyridine, phenyl dichlorophosphate / 1,2-dimethoxy-ethane / 18 h 3: 60 percent / borane-dimethyl sulphide complex (10 M) / tetrahydrofuran / 18 h View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
1: 23 percent / sodium hydroxide / H2O / 0 deg C, 30 min, 30-33 deg C, 2 h 2: 1) borane-dimethylsulphide complex, triethylamine; 2) aq. sodium hydroxide (2M) / 1) THF, 0 deg C, 15 min; 2) reflux, 6 h View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
1: With potassium carbonate in tetrahydrofuran; water T=0 - 4°C; 2 h; Industry scale; 2: With sodium hydroxide in tetrahydrofuran; water T=3 - 10°C; pH=13 - 13.5; 4.83333 h; Industry scale; 3: With hydrogenchloride in water T=3 - 6°C; pH=< 2; Industry scale;
参考文献
WO2011/23733 A1, ;
Page/Page column 19-20 ;
