反应条件
1: 1) n-butyllithium, diisopropylamine / 1) THF, hexane, -70 deg C, 1 h, 2) -70 deg C, 1 h
2: 81 percent / TiCl4 / CH2Cl2 / 1) -70 deg C, 2) -20 deg C, 2 h
3: 92 percent / ethyl orthoformate / p-TsOH*H2O / 5 h / Heating
4: 98 percent / KOH, NH2NH2*H2O / ethane-1,2-diol / 1.5 h / Heating
5: 1) NaH / 1) DMF, 1 h, 0 deg C, 2) a) 2 h, 0 deg C, b) RT
6: 3.6 percent / conc. HCl / 2 h / Ambient temperature
View Scheme
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Uchida, Kenshi; Tsubata, Kenji; Makino, Atsushi
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 300 - 304
