2-氯-N,N-二甲基乙胺合成路线 （共 199 条）
反应条件
potassium iodide in ethanol; benzene
参考文献
Albrecht,R.; Schroeder,E.
Justus Liebigs Annalen der Chemie, 1970 , vol. 736, p. 110 - 125
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide
1) THF, hexane, 0 deg C, 30 min, 2) THF, RT, 15 h; Yield given. Multistep reaction;
参考文献
Cohen, Victor I.; Jin, Biyun; Reba, Richard C.
Liebigs Annalen der Chemie, 1993 , # 7 p. 809 - 810
参考文献
Grail et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 1313
反应条件
sodium hydride in N,N-dimethyl-formamide
T=100°C; 4 h;
参考文献
Becker; Haddad
Tetrahedron, 1993 , vol. 49, # 4 p. 947 - 964
参考文献
Hromatka et al.
Monatshefte fuer Chemie, 1953 , vol. 84, p. 349,360
反应条件
sodium amide in toluene
参考文献
Krapcho; Turk; Piala
Journal of medicinal chemistry, 1968 , vol. 11, # 2 p. 361 - 364
反应条件
(i) NaOH, DMF, (ii) /BRN= 605280/; Multistep reaction;
参考文献
Aksanova,L.A. et al.
Pharmaceutical Chemistry Journal, 1971 , vol. 5, # 11 p. 647 - 649
Khimiko-Farmatsevticheskii Zhurnal, 1971 , vol. 5, # 11 p. 3 - 5
参考文献
Edwards,D. et al.
Journal of Pharmacy and Pharmacology, 1964 , vol. 16, p. 618 - 626
反应条件
sodium hydride in N,N-dimethyl-formamide
1.) 30 deg C, 2h, 2.) 50-55 deg C, 4h;
参考文献
Glushkov, R. G.; Vasil'evykh, L. G.; Kogan, Z. S.; Gorkin, V. Z.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 5 p. 337 - 341
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 5 p. 58 - 62
反应条件
1: Trriton X100 With N-benzyl-N,N,N-triethylammonium chloride in toluene
Heating / reflux;
2: 2-chloro-N,N-dimethylaminoethane in toluene
16 - 23 h; Heating / reflux;
参考文献
Dishman Pharmaceuticals and Chemicals Ltd.
Patent: EP1892235 A1, 2008 ;
Location in patent: Page/Page column 4 ;
