1,3,2-二噁唑噻吩-2,2-二氧化物合成路线 （共 24 条）
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexane T=-78 - 20°C; 3: With sulfuric acid in tetrahydrofuran; hexane 3 h; Heating; Further stages.;
参考文献
Schlaeger, Torsten; Oberdorf, Christoph; Tewes, Bastian; Wuensch, Bernhard
Synthesis, 2008 , # 11 p. 1793 - 1797
反应条件
1: 2-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.5 h; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexane T=20°C; 16 h; 3: With sulfuric acid in tetrahydrofuran; hexane 72 h; Heating; Further stages.;
参考文献
Schlaeger, Torsten; Oberdorf, Christoph; Tewes, Bastian; Wuensch, Bernhard
Synthesis, 2008 , # 11 p. 1793 - 1797
反应条件
tetrakis(dimethylamino)ethylene in tetrahydrofuran T=-20 - 20°C;
参考文献
Organic Letters, , vol. 4, # 26 p. 4671 - 4672
反应条件
1: thien-3-yl bromide With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexane T=-78 - 20°C; 3: With sulfuric acid in tetrahydrofuran; hexane 4 h; Heating; Further stages.;
参考文献
Schlaeger, Torsten; Oberdorf, Christoph; Tewes, Bastian; Wuensch, Bernhard
Synthesis, 2008 , # 11 p. 1793 - 1797
反应条件
1: benzo[b]thiophene in tetrahydrofuran; hexanes T=-50 - -40°C; 0.75 h; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexanes T=-40 - 20°C; 3: With acetyl chloride in methanol T=20°C; 4.25 h;
参考文献
Neurocrine Biosciences, Inc.
Patent: US2006/14797 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
1: dibenzopyrrole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexane T=-78 - 20°C; 25 h; Inert atmosphere; 3: With sulfuric acid in tetrahydrofuran; hexane; water 24 h; Reflux;
参考文献
Lueg, Corinna; Galla, Fabian; Frehland, Bastian; Schepmann, Dirk; Daniliuc, Constantin G.; Deuther-Conrad, Winnie; Brust, Peter; Wuensch, Bernhard
Archiv der Pharmazie, 2014 , vol. 347, # 1 p. 21 - 31
反应条件
1: 1-iodoheptadecafluorooctane With ethylmagnesium bromide in diethyl ether T=-78 - -40°C; 0.5 h; Inert atmosphere; 2: ethylene glycol cyclic sulfate With N,N'-dimethyl-N,N'-propyleneurea in diethyl ether T=-78 - -40°C; Inert atmosphere; 3: With water; potassium carbonate T=50°C; 3 h;
参考文献
Paterova, Jana; Skalicky, Martin; Rybackova, Marketa; Kvicalova, Magdalena; Cvacka, Josef; Kvicala, Jaroslav
Journal of Fluorine Chemistry, 2010 , vol. 131, # 12 p. 1338 - 1343
反应条件
1: heneicosafluoro-n-decyl iodide With ethylmagnesium bromide in diethyl ether T=-78 - -40°C; 0.5 h; Inert atmosphere; 2: ethylene glycol cyclic sulfate With N,N'-dimethyl-N,N'-propyleneurea in diethyl ether T=-78 - -40°C; Inert atmosphere; 3: With water; potassium carbonate T=50°C; 3 h;
参考文献
Journal of Fluorine Chemistry, , vol. 131, # 12 p. 1338 - 1343
反应条件
tetrakis(dimethylamino)ethylene in tetrahydrofuran T=-20 - 20°C;
参考文献
Organic Letters, , vol. 4, # 26 p. 4671 - 4672
反应条件
1: cyclobutyl alcohol With n-butyllithium in tetrahydrofuran; hexanes
T=0 - 10°C; 2 h;
2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexanes
T=15 - 20°C; 3 h;
3: With sulfuric acid; water in tetrahydrofuran; hexanes
18 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/49616 A1, 2005 ;
Location in patent: Page/Page column 145 ;
WO 2005/049616 A1
