2,3-二氨基苯甲酸甲酯合成路线 （共 23 条）
反应条件
1: hydroxylamine hydrochloride; sodium sulfate; hydrogenchloride / water / 65 °C / |Inert atmosphere 2: sulfuric acid / 2.5 h / 90 °C / |Inert atmosphere 3: sodium hydroxide; dihydrogen peroxide / water / 0 - 20 °C / |Inert atmosphere 4: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere 5: palladium 10 on activated carbon; hydrogen / methanol / 8 h / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8217 - 8231
反应条件
1: sodium hydroxide; dihydrogen peroxide / water / 0 - 20 °C / |Inert atmosphere 2: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / methanol / 8 h / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8217 - 8231
反应条件
toluene-4-sulfonic acid Reflux;
参考文献
Frohn, Mike; Viswanadhan, Vellarkad; Pickrell, Alexander J.; Golden, Jennifer E.; Muller, Kristine M.; Buerli, Roland W.; Biddlecome, Gloria; Yoder, Sean C.; Rogers, Norma; Dao, Jennifer H.; Hungate, Randall; Allen, Jennifer R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5023 - 5026
反应条件
1: 36 percent / acetic acid / 4 h / 90 - 100 °C 2: 1.) NaH / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 3 h View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
hydrogenchloride Addition; Heating;
参考文献
Griffin; Srinivasan; White; Bowman; Calvert; Curtin; Newell; Golding
Pharmaceutical Sciences, 1996 , vol. 2, # 1 p. 43 - 47
反应条件
in water 0.75 h; RefluxInert atmosphere;
参考文献
Wang, Jingjing; Zuo, Sujing; Chen, Weiqiang; Zhang, Xinrui; Tan, Kaixin; Tian, Yun; Wang, Jianhui
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8217 - 8231
反应条件
acetic acid T=90 - 100°C; 4 h;
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
acetic acid; sodium nitrite in water T=0°C; 1 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2007/113596 A1, 2007 ;
Location in patent: Page/Page column 85 ;
反应条件
in nitrobenzene
T=155 - 160°C; 3 h;
参考文献
Endo, Hitoshi
Patent: EP1481965 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
1: Et3N; DMAP / tetrahydrofuran / 25 °C
2: acetic acid / 120 °C
View Scheme
参考文献
Griffin; Srinivasan; White; Bowman; Calvert; Curtin; Newell; Golding
Pharmaceutical Sciences, 1996 , vol. 2, # 1 p. 43 - 47
