苯乙酸-Alpha,Alpha-d2合成路线 （共 12 条）
反应条件
lithium aluminium deuteride
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/16365 A1, 2010 ;
Location in patent: Page/Page column 20 ;
US 20100016365 A1
反应条件
lead(IV) acetate; lithium chloride in benzene 1) RT, 1 h 2) reflux, 1 h;
参考文献
Zamojski, Aleksander; Grzeszczyk, Barbara; Banaszek, Anna; Babinski, Jakub; Bordas, Xavier; et. al.
Carbohydrate Research, 1985 , vol. 142, p. 165 - 171
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
MacLean, Micheal J.; Walker, Scott; Wang, Tianfang; Eichinger, Peter C. H.; Sherman, Patrick J.; Bowie, John H.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 2 p. 371 - 377
反应条件
in water-d2
T=200°C; 9 h;
参考文献
Flakus, Henryk T.; Chelmecki, Michal
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2002 , vol. 58, # 9 p. 1867 - 1880
反应条件
NaOD; water-d2
4 h; Heating;
参考文献
Zamojski, Aleksander; Grzeszczyk, Barbara; Banaszek, Anna; Babinski, Jakub; Bordas, Xavier; et. al.
Carbohydrate Research, 1985 , vol. 142, p. 165 - 171
反应条件
magnesium in diethyl ether
T=-30°C;
参考文献
Heesing, Albert; Muellers, Wolfgang
Chemische Berichte, 1980 , vol. 113, # 1 p. 9 - 18
反应条件
1: Bu4NBr, NaOD / H2O / 2 h / Ambient temperature
2: 74 percent / NaOD, Bu4NBr / D2O / 5 h / Heating
View Scheme
参考文献
Kim, Sung Soo; Tuchkin, Alexey
Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 3821 - 3824
反应条件
1: 91 percent / phosphorus tribromide
View Scheme
参考文献
Dneprovskii, A. S.; Eliseenkov, E. V.; Mil'tsov, S. A.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 317 - 324
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 2 p. 365 - 373
反应条件
1: 85 percent / lithium aluminum deuteride / diethyl ether
2: 91 percent / phosphorus tribromide
View Scheme
参考文献
Dneprovskii, A. S.; Eliseenkov, E. V.; Mil'tsov, S. A.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 317 - 324
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 2 p. 365 - 373
反应条件
1: 90 percent / LiAlD4 / diethyl ether / Heating
2: 59 percent / SOCl2, Pyridin / CHCl3 / 20 °C
3: 65 percent / Mg / diethyl ether / -30 °C
View Scheme
参考文献
Heesing, Albert; Muellers, Wolfgang
Chemische Berichte, 1980 , vol. 113, # 1 p. 9 - 18
