6-甲氧基-1-萘满酮合成路线 （共 219 条）
反应条件
hydrogenchloride; sodium azide in water T=0 - 50°C; Schmidt reaction;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 31 ;
WO 2004/069256 A1
反应条件
in tetrahydrofuran T=40°C; 1 h;
参考文献
Tetrahedron, , vol. 62, # 8 p. 1726 - 1742
反应条件
(i) Mg, (ii) /BRN= 972739/; Multistep reaction;
参考文献
Steroids, , vol. 34, p. 619 - 629
反应条件
in tetrahydrofuran Title compound not separated from byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 23 p. 2719 - 2728
反应条件
1: (i) KBH4, (ii) aq. HCl 2: 3,4,5,6-tetrachloro-<1,2>benzoquinone / 1,2-dichloro-benzene / 22 - 39.8 °C View Scheme
参考文献
Jackman,L.M.; Thompson,D.T.
Journal of the Chemical Society, 1961 , p. 4794 - 4808
反应条件
1: CH3ONa / pyridine / 18 h / Ambient temperature 2: hydrazine hydrate / ethanol / 6 h / Heating View Scheme
参考文献
Parsia, Maria T. Di; Suarez, Cecilia; Vitolo, Maria J.; Marquez, Victor E.; Beyer, Bernardo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 117 - 119
反应条件
palladium dichloride in methanol T=40°C; 24 h; Inert atmosphereGreen chemistry; chemoselective reaction;
参考文献
Wang, Hu; Li, Li; Bai, Xing-Feng; Shang, Jun-Yan; Yang, Ke-Fang; Xu, Li-Wen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 341 - 347
反应条件
1: NaBH4 / methanol / 4 h / Ambient temperature 2: 93 percent / oxalic acid / H2O / 6 h / Heating 3: 1.) formic acid, 30 percent hydrogen peroxide; 2.) 20 percent H2SO4 / 1.) 35 deg C, 2 h, room temp., 12 h; 2.) reflux, 10 h View Scheme
参考文献
Pryde, David C.; Henry, Steven S.; Meyers
Tetrahedron Letters, 1996 , vol. 37, # 19 p. 3243 - 3246
反应条件
sodium t-butanolate; PdCl2(Amphos)2 in 1,4-dioxane T=100°C; 18 h; Inert atmosphere;
参考文献
WO2012/159981 A2, ;
Page/Page column 20 ;
反应条件
sodium t-butanolate; PdCl2(Amphos)2 in toluene T=60°C; 18 h; Inert atmosphere; Product distribution / selectivity;
参考文献
WO2012/159981 A2, ;
Page/Page column 19-20 ;
