1: diisopropylamine, n-BuLi / tetrahydrofuran / 1.75 h / 0 °C
2: NaOH / H2O
View Scheme
参考文献
Spencer, Robin W.; Tam, Tim Fat; Thomas, Everton; Robinson, Valerie J.; Krantz, Allen
Journal of the American Chemical Society, 1986 , vol. 108, # 18 p. 5589 - 5597
1: triphenylmethyl sodium / und Aethylierung der entstandenen Natriumverbindung mit Benzolsulfonsaeure-aethylester oder auch mit Aethyljodid
2: liquid NH3; sodium amide
View Scheme
参考文献
Hudson; Hauser
Journal of the American Chemical Society, 1940 , vol. 62, p. 2459
Journal of the American Chemical Society, 1941 , vol. 63, p. 3161
1: 3-Methyl-butanoic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h; Inert atmosphereSchlenk technique;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C; 2 h; Inert atmosphereSchlenk technique;
参考文献
Nitsch, Dominik; Huber, Stefan M.; Poethig, Alexander; Narayanan, Arjun; Olah, George A.; Prakash, G. K. Surya; Bach, Thorsten
Journal of the American Chemical Society, 2014 , vol. 136, # 7 p. 2851 - 2857
