1-氨基-3,5-二甲苯合成路线 （共 187 条）
反应条件
1: (i) (diazotization), aq. HBr, (ii) Cu 2: (i) Mg, (ii) /BRN= 1209228/ View Scheme
参考文献
van Zanten,B.; Nauta,W.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1211 - 1222
反应条件
1: With sulfuric acid; sodium nitrite in water; acetone T=0°C; 1.75 h; 2: With potassium iodide in water; acetone T=20°C;
参考文献
Xiang, Yanqiao; Caron, Pierre-Yves; Lillie, Brett M.; Vaidyanathan, Rajappa
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 116 - 119
反应条件
1: 48percent tetrafluoroboric acid, sodium nitrite / methanol; H2O 2: Heating 3: potassium permanganate, potassium carbonate / H2O / 70 h / Heating View Scheme
参考文献
Gumbley, Stewart J.; Stewart, Ross
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 3 p. 529 - 532
反应条件
sodium hydroxide in dichloromethane; water 18 h;
参考文献
Stewart, Andrew O.; Kolasa, Teodozyj
Patent: US2003/232836 A1, 2003 ;
Location in patent: Page 44 ;
US 20030232836 A1
参考文献
Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.
Patent: US2004/29887 A1, 2004 ;
反应条件
in acetone 0.5 h; Heating;
参考文献
Rasmussen, C. R.; Villani, F. J.; Weaner, L. E.; Reynolds, B. E.; Hood, A. R.; et al.
Synthesis, 1988 , # 6 p. 456 - 459
反应条件
in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan S.; PHUAN, Puay-Wah; KURTH, Mark J.; KNAPP, John
Patent: WO2012/166654 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/166654 A1
反应条件
triethylamine in dichloromethane
T=201°C; 1 h;
参考文献
Louillat, Marie-Laure; Biafora, Agostino; Legros, Fabien; Patureau, Frederic W.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3505 - 3509
Angew. Chem., 2014 , vol. 53, # 13 p. 3573 - 3577,5
反应条件
acetic anhydride in ethyl acetate; toluene
参考文献
Merck and Co., Inc.
Patent: US5348955 A1, 1994 ;
US 5348955 A
反应条件
T=150°C; microwave irradiation;
参考文献
Wang, Xiao-Jian; Yang, Qian; Liu, Fei; You, Qi-Dong
Synthetic Communications, 2008 , vol. 38, # 7 p. 1028 - 1035
