1-氨基-3,5-二甲苯合成路线 （共 187 条）
反应条件
sodium nitrate; methanesulfonic acid; sodium chloride; ammonia; Copper(I)chloride in hydrogenchloride; water; acetic acid
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4585866 A1, 1986 ;
反应条件
hydrogenchloride; sodium nitrite in water
参考文献
Rohm and Haas Company
Patent: US5500405 A1, 1996 ;
反应条件
hydrogenchloride Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl;
参考文献
Gross, Margaret L.; Blank, David H.; Welch, Willard M.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2104 - 2109
反应条件
zinc diacetate in quinoline T=180 - 230°C; Yield given;
参考文献
Rademacher, Andreas; Maerkle, Suse; Langhals, Heinz
Chemische Berichte, 1982 , vol. 115, # 8 p. 2927 - 2934
反应条件
1: With [Pd(dppe)(H2O)2](TfO)2 in 1,4-dioxane T=80°C; 22 h; 2: With silica gel in dichloromethane T=20°C; 2 h;
参考文献
Shimada, Tomohiro; Bajracharya, Gan B.; Yamamoto, Yoshinori
European Journal of Organic Chemistry, 2005 , # 1 p. 59 - 62
反应条件
1: With hydrogenchloride; hydrofluoroboric acid; sodium nitrite in water T=25°C; Balz-Schiemann Reaction; 0.00277778 h; 2: in chlorobenzene T=110°C; Balz-Schiemann Reaction; 0.0166667 h;
参考文献
Yu, Zhi-Qun; Lv, Yan-Wen; Yu, Chuan-Ming; Su, Wei-Ke
Tetrahedron Letters, 2013 , vol. 54, # 10 p. 1261 - 1263
反应条件
2,6-dimethylpyridine; air; octane-1-acetic acid; copper diacetate in toluene T=20°C; 24 h;
参考文献
Tzschucke, C. Christoph; Murphy, Jaclyn M.; Hartwig, John F.
Organic Letters, 2007 , vol. 9, # 5 p. 761 - 764
反应条件
sodium t-butanolate in toluene T=100 - 110°C; Buchwald-Hartwig amination; 20 h; Inert atmosphereSealed vial;
参考文献
Lundgren, Rylan J.; Sappong-Kumankumah, Antonia; Stradiotto, Mark
Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1983 - 1991
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate in toluene T=20 - 105°C; Inert atmosphere;
参考文献
Ackermann, Lutz; Sandmann, Rene; Song, Weifeng
Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in diethyl ether; cyclohexane T=50°C; 48 h; Inert atmosphere;
参考文献
Truong, Thanh; Daugulis, Olafs
Organic Letters, 2012 , vol. 14, # 23 p. 5964 - 5967
