1-氨基-3,5-二甲苯合成路线 （共 187 条）
参考文献
Bennet; Slebocka-Tilk; Brown; Guthrie, J. Peter; Jodhan
Journal of the American Chemical Society, 1990 , vol. 112, # 23 p. 8497 - 8506
反应条件
1: 1) conc. HCl, NaNO2, 2) 1M KOH / 1) water, 10 min, ice bath, 2) 30 min, ice bath 2: 25 percent / Pd(OAc)2, 48percent HBF4 / acetonitrile / 1 h View Scheme
参考文献
Gross, Margaret L.; Blank, David H.; Welch, Willard M.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2104 - 2109
反应条件
in anhydrous xylene T=130°C; 1 h;
参考文献
Heitbaum, Maja; Froehlich, Roland; Glorius, Frank
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 357 - 362
反应条件
in N,N-dimethyl-formamide T=125°C; Microwave irradiation;
参考文献
Knapp, John M.; Zhu, Jie S.; Wood, Alex B.; Kurth, Mark J.
ACS Combinatorial Science, 2012 , vol. 14, # 2 p. 85 - 88
参考文献
Carbide and Carbon Chem.Corp.
Patent: US2152787 , 1937 ;
反应条件
1: (i) (diazotization), aq. HBr, (ii) Cu 2: (i) Mg, (ii) /BRN= 1209228/ 3: SOCl2 View Scheme
参考文献
van Zanten,B.; Nauta,W.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1211 - 1222
反应条件
in methanol-d4 T=34.85°C; Rearrangement; KineticsActivation energy; Further Variations:Temperatures;
参考文献
Campbell, John J.; Glover, Stephen A.
Journal of Chemical Research, Miniprint, 1999 , # 8 p. 2075 - 2096
反应条件
benzoyl chloride in acetone 0.5 h; Heating;
参考文献
Agarwal, Shikha; Agarwal, Dinesh Kumar; Gautam, Naveen; Agarwal, Kshamta; Gautam, Dinesh Chandra
Journal of the Korean Chemical Society, 2014 , vol. 58, # 1 p. 33 - 38
反应条件
hydrogenchloride in water T=100°C; 16 h;
参考文献
Hay, Michael P.; Turcotte, Sandra; Flanagan, Jack U.; Bonnet, Muriel; Chan, Denise A.; Sutphin, Patrick D.; Nguyen, Phuong; Giaccia, Amato J.; Denny, William A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 787 - 797
参考文献
Mead Johnson and Company
Patent: US4223031 A1, 1980 ;
