反应条件
1: piperidine; 2,4,6-trichloro-1,3,5-triazine in diethyl ether
T=-45°C; Substitution; 0.5 h;
2: 2-amino-2,3-dihydro-1H-indene With triethylamine in tetrahydrofuran
T=20°C; Substitution;
参考文献
Hajduk, Philip J.; Dinges, Juergen; Schkeryantz, Jeffrey M.; Janowick, David; Kaminski, Michele; Tufano, Michael; Augeri, David J.; Petros, Andrew; Nienaber, Vicki; Zhong, Ping; Hammond, Rachel; Coen, Michael; Beutel, Bruce; Katz, Leonard; Fesik, Stephen W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3852 - 3859